Inhibition of membrane potential-dependent amino acid transport by daptomycin.
نویسندگان
چکیده
Daptomycin inhibits the formation of UDP-N-acetylmuramyl-pentapeptide in Bacillus megaterium by inhibiting active transport of amino acids incorporated into the pentapeptide. The ability of daptomycin to inhibit active transport and peptidoglycan formation may be due to its ability to disrupt the transmembrane electrochemical gradient.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 35 12 شماره
صفحات -
تاریخ انتشار 1991